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The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine

S. W. Schneller ; Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA
J. L. May ; Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA
E. De Clercq ; The Rega Institute, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Sažetak

The preparation of 8-amino-3-[(2-hydroxyethoxy)methyl]-1,2,4-
triazolo[4,3-a]pyrazine (IV) as an analogue of 9-[(2-hydroxyethoxy)
methyl]guanine and 9-(S)-(2,3-dihydroxypropyl)adenine is described
from the reaction of 3-chloro-2-hydrazinopyrazine (V) and ethyl 2-(2-acetoxyethoxy)thioacetimidate (IXg) followed by treatment with ammonia. Compound IV was found to lack antiviral properties towards herpes simplex I and II, vaccinia virus, vesicular stomatitis virus, measles, reovirus type 1, parainfluenza virus type 3, Sindbis virus, Coxsackie type B4 virus, and poliovirus type.

Ključne riječi

Hrčak ID:

177595

URI

https://hrcak.srce.hr/177595

Datum izdavanja:

16.5.1986.

Posjeta: 608 *