Croatica Chemica Acta, Vol. 58 No. 2, 1985.
Izvorni znanstveni članak
Erythromycin Series. IX. Acid Solvolysis of N-(4-Substituted-Benzenesulfonyl) Erythromycylamines
Gorjana Radobolja
; Research Institute PLIVA, L. Ribara 89, 41000 Zagreb
Zrinka Tamburašev
; Research Institute PLIVA, L. Ribara 89, 41000 Zagreb
Tomislav Lazarevski
; Research Institute PLIVA, L. Ribara 89, 41000 Zagreb
Slobodan Djokić
; Research Institute PLIVA, L. Ribara 89, 41000 Zagreb
Sažetak
Degradation of new erythromyein derivatives, N-(4-substituted-benzenesulfonyl)erythromycylamines, at pR = 1.2 was studied
both at 26aC and 36aC. Degradation products were isolated
and eharaeterized. Under the eonditions examined hydrolysis oeeurred at the C-3 glycosidic linkage, and N-(4-substituted-benzenesulfonyl)-3- des-cladinosyl-erythromyeylamines and sugar cladinose were isolated and identified as degradation products by IR, NMR and mass speetroscopy. Hydrolytic produets were separated by TLe from the parent compounds and quantitatively analysed by densitometry. The
pseudo first-order rate eonstants of hydroslysis were evaluated.
Ključne riječi
Hrčak ID:
177755
URI
Datum izdavanja:
21.7.1985.
Posjeta: 607 *