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The influence of early nutrition on the nutrition status and course of disease in patients with acute pancreatitis

Dubravka Holik ; Sveučilišta Josipa juraja Strossmayera u Osijeku, Medicinski fakultet
Aleksandar Včev ; Sveučilište Josipa juraja Strossmayera u Osijeku, Medicinski fakultet
Ivan Miškulin ; Sveučilište Josipa Jurja strossmayera u Osijeku, Medicinski fakultet
Sanda Goll-Barić ; Roche d.o.o., Zagreb
Boris Dželalija orcid id ; Opća bolnica Zadar, Odjel za infektologiju
Maja Miškulin ; Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet

Puni tekst: hrvatski pdf 841 Kb

str. 6-12

preuzimanja: 577



Aim. The aim of this study was to evaluate the effects of early enteral nutrition (EN) and total parenteral nutrition (TPN) to nutritional status and development of the disease in patients suffering from acute pancreatitis.
Patients and methods. 35 patients suffering from average severe acute pancreatitis were included in this randomized controlled trial. The patients were divided into two groups, according to the type of nutritional support. Those receiving enteral nutrition were given Alitraq, Abbott, 25-30 kcak/kg via nasojejunal tube with general supportive treatment. Other patients receiving total parenteral nutrition were given this nutrition in continuous infusion through the central venous catheter with general supportive treatment.
Results. Mean value of CRP in patients on EN demonstrated more pronounced decrease on day 7 of the treatment vs. TPN (101.5 : 142.6). A decrease in the body mass index (BMI) was higher in the TPN group when compared to initial values (7.4%), whereas in patients on EN group after initial decrease, the values approached baseline values. The values of serum calcium recovered faster and reached higher values in the EN group (2.11 ± 0.11mmol/L) vs. patients in TPN group (2.06 ± 0.16 mmol/L). An increase in the serum albumin levels in comparison to baseline values was 6.5% in EN group vs. 0.2% in TPN group of patients.
The length of hospitalization was on average two days shorter in patients receiving EN. Complication incidence was similar in both groups.
Conclusion. EN is equally efficient and safe in treatment of acute pancreatitis as standard nutritional support i.e. total parenteral nutrition.

Ključne riječi

acute pancreatitis; enteral nutrition; total parenteral nutrition

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Podaci na drugim jezicima: hrvatski

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