Izvorni znanstveni članak

https://doi.org/10.20471/acc.2016.55.04.07

Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy

Marek Iłżecki ; Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland
Joanna Iłżecka ; Indepondent Neurological Rehabilitation Unit, Medical University of Lublin, Lublin, Poland
Stanisław Przywara ; Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland
Piotr Terlecki ; Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland
Aneta Grabarska ; Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland
Andrzej Stepulak ; Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland
Tomasz Zubilewicz ; Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland

Sažetak

In patients with atherosclerotic stenosis of the extracranial segment of internal carotid artery, surgical intervention is an effective method to prevent cerebral ischemic stroke. However, this surgical procedure may cause vascular brain damage. The aim of the study was to investigate consequential brain ischemia-reperfusion injury by measuring the cerebral specific marker, neuronspecific enolase (NSE), in serum of patients having undergone internal carotid endarterectomy (CEA). The study involved 25 patients that underwent CEA due to internal carotid artery stenosis. Blood samples were obtained from each patient on three occasions: within 24 h prior to surgery, 12 h after surgery, and 48 h after surgery. Serum NSE levels were measured by a commercially available enzymelinked immunosorbent assay. The study showed that serum NSE level was statistically significantly increased 48 h after CEA as compared with the level 12 h after surgery and the level before surgery (p<0.05). Difference in serum NSE between the level before surgery and 12 h after CEA was not statistically significant (p>0.05). Data from our study showed CEA to affect serum NSE in patients with significant internal carotid artery stenosis. Thus, serum NSE may be used as a biochemical marker of brain ischemia-reperfusion injury following CEA.

Ključne riječi

Carotid endarterectomy; Ischemic stroke; Neuron-specific enolase

Hrčak ID:

177943

URI

https://hrcak.srce.hr/177943

Datum izdavanja:

15.12.2016.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.799 *