Izvorni znanstveni članak
https://doi.org/10.1515/aiht-2017-68-2919
Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?
Zorica Bulat
orcid.org/0000-0001-9830-8772
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy - University of Belgrade, Belgrade, Serbia
Danijela Đukić-Ćosić
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Biljana Antonijević
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Aleksandra Buha
orcid.org/0000-0002-6942-7040
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Petar Bulat
orcid.org/0000-0002-4311-8960
; Institute of Occupational Health, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Zoran Pavlović
; Institute for Public Health Požarevac, Požarevac, Serbia
Vesna Matović
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Sažetak
The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg-1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg-1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.
Ključne riječi
biometals; biometal ratio; blood; bones; copper; kidney; liver; magnesium; interactions
Hrčak ID:
178116
URI
Datum izdavanja:
23.3.2017.
Posjeta: 2.083 *