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Croatian Medical Journal, Vol. 57 No. 5, 2016.

Original scientific paper

https://doi.org/10.3325/cmj.2016.57.482

Endothelial lipase plasma levels are increased in both sexes in stable coronary artery disease and only in women with acute coronary syndrome but not associated with the severity of coronary artery disease

Matias Trbušić ; University of Zagreb School of Medicine, Zagreb, Croatia
Ines Potočnjak ; Charity University Hospital Centre,Zagreb, CroatiaDepartment of Medicine, Sisters of
Beate Tiran ; Clinical Institute for Medical and Chemical Laboratory DiagnosticsMedical University of Graz, Graz, Austria
Tomislava Bodrožić-Džakić ; Department of Medicine University Hospital Dubrava,Zagreb, Croatia
Milan Milošević ; Department for Environmental and Occupational Health, AndrijaŠtampar School of Public Health,Zagreb, Croatia
Vesna Degoricija ; University of Zagreb School of Medicine, Zagreb, Croatia
Saša Frank ; Institute of Molecular Biology and Biochemistry, Center of MolecularMedicine, Medical University ofGraz, Graz, Austria

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Abstract

Aim To investigate whether endothelial lipase (EL) plasma
levels are increased in stable coronary artery disease
(sCAD) and acute coronary syndrome (ACS) patients, as
well as to test the association of EL plasma levels and the
severity of CAD and sex.
Methods The study was performed as a single-center,
cross-sectional, observational research on 72 sCAD and
187 ACS patients in the Sisters of Charity University Hospital
Centre, Zagreb, Croatia, between December 1, 2011
and December 1, 2012. EL plasma levels were measured
using ELISA.
Results EL plasma levels were significantly higher in sCAD
patients (median 311.3 pg/mL, interquartile range [IQR]
250.4-422.6 pg/mL) than in ACS patients (median = 258.7
pg/mL, IQR = 162.1-356.0 pg/mL; P < 0.001). EL levels in female
ACS patients were significantly higher (median 314.5
pg/mL, IQR 218.3-420.8 pg/mL) than in male ACS patients
(median 225.4 pg/mL, IQR 148.7320.1 pg/mL; P < 0.001)
and similar to the EL levels in the sCAD patients. There was
no significant correlation between EL plasma levels and
the GENSINI score and between EL plasma levels and the
number of atherosclerotic coronary artery segments in either
the ACS (rho = -0.09, P = 0.247; rho = 0.12, P = 0.106, respectively)
or sCAD group (rho = 0.04, P = 0.771; rho = 0.06,
P = 0.643, respectively).
Conclusion Our results suggest that EL plasma levels discriminate
male but not female patients with different clinical
presentations of CAD, as well as female and male ACS
patients. EL plasma levels are not significantly correlated
with CAD severity.

Keywords

Hrčak ID:

181390

URI

https://hrcak.srce.hr/181390

Publication date:

15.10.2016.

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