Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.548
Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction
Iwona Kurkowska-Jastrzębska
; 12nd Department of NeurologyInstitute of Psychiatry and Neurology, Warsaw, Poland
Michał A. Karliński
; 12nd Department of NeurologyInstitute of Psychiatry and Neurology, Warsaw, Poland
Beata Błażejewska-Hyżorek
; 12nd Department of NeurologyInstitute of Psychiatry and Neurology, Warsaw, Poland
Iwona Sarzyńska-Długosz
; 12nd Department of NeurologyInstitute of Psychiatry and Neurology, Warsaw, Poland
Krzysztof J. Filipiak
; 1st Department of Cardiology Medical University of Warsaw, Warsaw, Poland
Anna Członkowska
; Department of Experimental and Clinical Pharmacology, MedicalUniversity of Warsaw, Warsaw, Poland
Sažetak
Aim To test if circulating levels of markers of inflammation,
endothelial function, and chronic infections, as well as association
between these markers and carotid intima media
thickness (CIMT), depend on the stage of atherosclerosis
expressed as a history of a major vascular event.
Methods The associations were analyzed separately in 75
healthy controls, 79 patients 3-6 months after the first-ever
non-cardioembolic ischemic stroke (IS), and 37 patients 3-6
months after the first-ever myocardial infarction (MI). Data
were collected prospectively in 2005. We measured high
sensitivity C-reactive protein (hs-CRP), procalcitonin, E-selectin,
intercellular adhesion molecule-1 (ICAM-1), serum
level of immune complexes (IC), and identified antibodies
against Herpes simplex virus type 1 (HSV), Cytomegalovirus,
Chlamydia pneumonia, and Helicobacter pylori. Correlations
with CIMT were determined using Pearson R and verified
after adjustment for age, sex, hypertension, diabetes,
and statin therapy.
Results Median ICAM-1 concentration was significantly
lower in controls than in post-IS patients (188 μg/L vs 215
μg/L), and significantly lower in post-IS patients than in
post-MI patients (215 μg/L vs 260 μg/L). Control patients
also had significantly lower IC level (0.03 U/L) and HSV antibody
index (6.0) compared to both post-IS (0.6 U/L, 9.6)
and post-MI (0.4 U/L, 9.2) patients. CIMT was correlated
with age (Pearson R = 0.38, P = 0.001) in the control group,
immune complexes (R = 0.26, P = 0.023) in the post-IS
group, and with hs-CRP (R = 0.40, P = 0.017) in the post-MI
group. These correlations were confirmed using multiple
regression analysis.
Conclusions Our study supports linear correlations between
CIMT and IC and hs-CRP levels. However, these associations
seem to depend on the type of vascular burden.
Ključne riječi
Hrčak ID:
181394
URI
Datum izdavanja:
15.12.2016.
Posjeta: 866 *