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Croatian Medical Journal, Vol. 57 No. 6, 2016.

Izvorni znanstveni članak

https://doi.org/10.3325/cmj.2016.57.558

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Magdalena Krbot Skorić orcid id orcid.org/0000-0002-1087-3732 ; University Hospital Center Zagreb, Department of Neurology, ReferralCenter for Autonomic NervousSystem Disorders, Zagreb, Croatia
Ivan Adamec ; University Hospital Center Zagreb, Department of Neurology, ReferralCenter for Autonomic NervousSystem Disorders, Zagreb, Croatia
Luka Crnošija ; School of Medicine, University of Zagreb, Zagreb, Croatia
Tereza Gabelić ; University Hospital Center Zagreb, Department of Neurology, ReferralCenter for Autonomic NervousSystem Disorders, Zagreb, Croatia
Barbara Barun ; University Hospital Center Zagreb, Department of Neurology, ReferralCenter for Autonomic NervousSystem Disorders, Zagreb, Croatia
Ivana Zadro ; University Hospital Center Zagreb, Department of Neurology, ReferralCenter for Autonomic NervousSystem Disorders, Zagreb, Croatia
Silva Butković Soldo ; University Hospital Centre Osijek Department of Neurology, Osijek, Croatia
Mario Habek orcid id orcid.org/0000-0002-3360-1748 ; University Hospital Center Zagreb, Department of Neurology, ReferralCenter for Autonomic NervousSystem Disorders, Zagreb, Croatia

Puni tekst: engleski pdf 116 Kb

verzije

str. 558-565

preuzimanja: 387

citiraj

Sažetak

Aim To test the hypothesis that tSSEP findings reflect clinical
and MRI MS lesions, the aim of this study was to investigate
tSSEP changes in patients with clinically isolated
syndrome (CIS) in relation to clinical and brainstem MRI
findings. The second aim was to investigate whether the
interpretation of the tSSEP results in the form of the tSSEP
score enables better evaluation of the afferent trigeminal
pathway involvement than analyzing each tSSEP parameter
separately.
Methods 115 consecutive CIS patients were enrolled from
August 1, 2014 until March 1, 2016. Facial sensory symptoms
and brainstem MRI (1.5 T) lesions were analyzed.
tSSEP testing was performed for each patient from the raw
tSSEP data. The tSSEP score was calculated separately for
the left and right side (according to the cut-off values for
absent response and prolonged latency of the main component,
P1 (0 = normal response, 1 = prolonged latency,
3 = absent response) and the two values were summed.
Results There was no difference in the absolute values
of the tSSEP variables regarding the presence of clinical
symptoms. No association was found between tSSEP abnormalities
and clinical symptoms (P = 0.544). Brainstem lesions
(midbrain and pons) were associated with the absent
tSSEP responses (P = 0.002 and P = 0.005, respectively). tSSEP
score was significantly higher in patients with brainstem lesions
(P = 0.01), especially midbrain (P = 0.004) and pontine
(P = 0.008) lesions. Binary logistic regression showed that
tSSEP score had a significant effect on the likelihood that
patients have midbrain MR lesions, χ2(1) = 6.804, P = 0.009;
and the model correctly classified 87% of cases.
Conclusions The consistent finding of this study was the
association between tSSEP and midbrain lesions on MRI,
indicating that tSSEP evaluates proprioception of the face.
This study establishes the value of tSSEP in assessing brainstem
function in early multiple sclerosis.

Ključne riječi

Hrčak ID:

181395

URI

https://hrcak.srce.hr/181395

Datum izdavanja:

15.12.2016.

Posjeta: 847 *