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Melanie-Ivana Čulo
Jadranka Morović-Vergles

Puni tekst: hrvatski pdf 144 Kb

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Rheumatic diseases are chronic infl ammatory disorders with ongoing infl ammation that causes tissue
damage. Infl ammatory and damaged cells synthetize and release many diff erent intracellular substances which can
activate highly specialized subsets of primary sensory neurons called nociceptors. Some of these proinfl ammatory
mediators directly activate the nociceptor terminal and produce pain (such as hydrogen ion, adenosine triphosphate,
and bradykinin), and others sensitize the terminal so that it becomes hypersensitive to subsequent and non-noxious
stimuli (such as prostaglandin E2 and bradykinin). Acute pain has a protective role since it induces behavior that promotes
healing and recovery, such as immobilization which limits tissue damage. Chronic pain is unhelpful pain that
tends to be out of proportion to the actual tissue damage and persists long aft er the tissues have healed, so that the pain
becomes the problem rather than the tissues of origin. Chronic pain aff ects the physical and mental status and causes
impairment of quality of life as well as work disability. For rheumatologists the assessment and treatment of pain is a
very important integral part of patient care, and understanding the etiology and pathogenesis of pain is necessary to
fi nd adequate modalities of treatment to prevent suff ering.

Ključne riječi

Rheumatic diseases – physiopathology; Pain – classifi cation, etiology, physiopathology; Chronic pain – physiopathology; Infl ammation – physiopathology; Nociceptors – physiology; Pain perception – physiology

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