Izvorni znanstveni članak

https://doi.org/10.20471/acc.2017.56.01.09

Bone Mineral Density in Relation to Metabolic Syndrome Components in Postmenopausal Women With Diabetes Mellitus Type 2

Ines Bilić-Ćurčić ; Clinical Department of Endocrinology and Metabolism Disorders, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia
Sandra Makarović ; Clinical Department of Cardiovascular Diseases and Intensive Care, Osijek Universiyt Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia
Ivan Mihaljević ; Clinical Department of Nuclear Medicine and Radiation Protection, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia
Maja Franceschi ; Clinical department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia
Tomislav Jukić ; School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia; Clinical Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, Zagreb, Croatia

Sažetak

Diabetes mellitus type 2 is associated with greater bone mineral density (BMD) due to obesity, although rapid bone loss observed over time could be explained by elevated chronic inflammation. The objective of this study was to investigate the relationship between central adiposity and hyperinsulinemia, as well as inflammation markers with vertebral and femoral BMD and bone turnover markers in postmenopausal women with type 2 diabetes. Femoral and vertebral BMD, osteocalcin, pyrilinks D, beta-CrossLaps (B-CTx), insulin, C-reactive protein (CRP), fibrinogen and plasminogen activator inhibitor-1 (PAI-1) were measured in 114 postmenopausal female patients with diabetes type 2. The patients of similar age, HbA1c levels and diabetes duration were divided into 2 groups based on their body mass index (BMI) values: lower or equal to 27 kg/m2(31 patients) and higher than 27 kg/m2(83 patients). Lower levels of osteocalcin (p=0.001), B-CTx (p=0.000007) and pyrilinks D (p=0.0365), and higher femoral BMD (p=0.00006), insulin level (p=0.0002), PAI-1 (p=0.00000) and CRP (p=0.002) were found in the overweight group. There were no significant differences in vertebral BMD and fibrinogen. Osteocalcin and B-CTx showed inverse correlation, and femoral BMD positive correlation with waist circumference, insulin level and PAI-1. This suggests that abdominal obesity and hyperinsulinemia as components of the metabolic syndrome could increase femoral BMD by lowering bone rate. In addition, the only inflammation marker linked with femoral BMD was PAI-1, which is associated with increased mineralization of cortical bone in mouse models.

Ključne riječi

Diabetes mellitus, type 2; Adiposity; Hyperinsulinism; Inflammation; Bone density; Menopause

Hrčak ID:

184302

URI

https://hrcak.srce.hr/184302

Datum izdavanja:

1.3.2017.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.899 *