Izvorni znanstveni članak

https://doi.org/10.11613/BM.2017.030702

Changing reference intervals for haemoglobin in Denmark: Clinical and financial aspects

Judith Ryberg-Nørholt ; Department of Haematology, Odense University Hospital, Odense, Denmark
Henrik Frederiksen ; Department of Haematology, Odense University Hospital, Odense, Denmark
Mads Nybo ; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

Sažetak

Introduction: Based on international experiences and altering demography the reference intervals (RI) for haemoglobin (Hb) concentrations in
blood were changed in Denmark in 2013 from 113 - 161 g/L to 117 - 153 g/L for women and from 129 - 177 g/L to 134 - 170 g/L for men. The aim
of this study was to determine the derived change in prevalence of anaemia and the change in yearly health care costs of diagnostic investigations
associated with the expected, as we hypothesized, increased prevalence and health care costs.
Materials and methods: Data from 96,314 non-hospitalised patients (55,341 females and 40,973 males, aged 18 - 105 years) from general practitioners
and community specialists of Funen, Denmark, were extracted from the laboratory information system. The prevalence of anaemia according
to the new and the old RI were investigated, and additional costs were calculated based on estimated additional blood analyses and nationally
recommended endoscopic procedures.
Results: Changing the Hb RI increased the number of anaemic patients by 52% (3450 patients) over a two-year period. With new RI the proportion
of anaemic elderly above 80 years was 20.5% for females and 43.9% for males. Annual costs of derived additional assessments due to the altered RI
were estimated to be 5.7 million €, which equals the cost of 1214 knee replacement surgeries in Denmark.
Conclusions: Changing the Hb RI has been expensive, despite the fact that no outcome studies have justified the alteration. The methodological
approach for establishing new RI, here particularly for Hb, should be thoroughly considered. In general, physicians should use RI with caution.

Ključne riječi

anaemia; haematology; haemoglobins; reference values

Hrčak ID:

187585

URI

https://hrcak.srce.hr/187585

Datum izdavanja:

15.10.2017.

Posjeta: 1.188 *