Acta Pharmaceutica, Vol. 58 No. 1, 2008.
Izvorni znanstveni članak
https://doi.org/10.2478/v10007-007-0042-4
Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives
MOHAMED IBRAHIM HEGAB
NABIL MAHMOUD YOUSEF
HANY FATHY NOUR
MOHEY ELLITHEY
MAHMOUD SOLIMAN
Sažetak
Some new hydrazono- 5a,b, thiosemicarbazono- 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding β-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.
Ključne riječi
β-chlorocarbaldehyde; hydrazones; thiosemcarbazones; oxime ethers; anti-inflammatory activity; ulcerogenic activity
Hrčak ID:
17851
URI
Datum izdavanja:
1.3.2008.
Posjeta: 3.160 *