Izvorni znanstveni članak
https://doi.org/10.22514/SV132.112017.15
The effect of erythropoietin on chloride levels during hypoxia reoxygenation injury in rats
CONSTANTINOS TSOMPOS
orcid.org/0000-0003-3469-3127
; Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios”, Thessalonik,Greece
CONSTANTINOS PANOULIS
KONSTANTINOS TOUTOUZAS
AGGELIKI TRIANTAFYLLOU
GEORGE ZOGRAFOS
APOSTOLOS PAPALOIS
Sažetak
Objective. This experimental study examined
the effect of erythropoietin (Epo) in
a rat model and particularly in a hypoxiareoxygenation
(HR) protocol. The effect of
that molecule was studied biochemically
using blood mean chloride (Cl) levels.
Materials and methods. 40 rats of mean
weight 247.7 g were used in the study. Cl
levels were measured at 60 min (groups A
and C) and at 120 min (groups B and D) of
reoxygenation. Erythropoietin was administered
only in groups C and D.
Results. Epo administration non-significantly
decreased Cl levels by 1.07%+0.91%
(p=0.2635). Reoxygenation time nonsignificantly
decreased Cl levels by
0.68%+0.92% (P= 0.4457). However, erythropoietin
administration and reoxygenation
time together produced a non-significant
combined effect in decreasing Cl levels
by 0.74%+0.54% (P= 0.1701).
Conclusions. Epo administration, reoxygenation
time and their interaction have
non-significant, short-term, decreasing effects
on Cl levels.
Ključne riječi
chloride; hypoxia; erythropoietin; reoxygenation
Hrčak ID:
190623
URI
Datum izdavanja:
12.12.2017.
Posjeta: 657 *