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Pregledni rad

https://doi.org/10.1515/aiht-2017-68-2994

Hepatotoxicity associated with statins

Bensu Karahalil orcid id orcid.org/0000-0003-1625-6337 ; Toxicology Department, Faculty of Pharmacy, Gazi University Ankara, Turkey
Emine Hare ; Toxicology Department, Faculty of Pharmacy, Gazi University Ankara, Turkey
Göksel Koç ; Toxicology Department, Faculty of Pharmacy, Gazi University Ankara, Turkey
İrem Uslu ; Toxicology Department, Faculty of Pharmacy, Gazi University Ankara, Turkey
Kerem Şentürk ; Toxicology Department, Faculty of Pharmacy, Gazi University Ankara, Turkey
Yağmur Özkan ; Toxicology Department, Faculty of Pharmacy, Gazi University Ankara, Turkey


Puni tekst: engleski pdf 324 Kb

str. 254-260

preuzimanja: 4.837

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Sažetak

Treatment with statins is known all over the world. They are generally considered safe at therapeutic doses. Nevertheless, clinical trials are not enough to assess their scarce adverse effects such as idiosyncratic drug induced liver injury (DILI). Due to some conditions, such as concomitant usage (drug-drug interaction using an identical metabolising enzyme) and genetic polymorphisms, there is an increasing concern about their safety. Hepatotoxicity and rhabdomyolysis have begun to appear in published studies. Most of investigations have focused on both these adverse effects and mechanisms of drug induced toxicity. The present review has attempted to compile almost all of the existing studies on the hepatotoxicity of statins but not rhabdomyolysis. The aim of our study is to provide an overview of the studies on the statin-associated hepatotoxicity and to discuss the published studies. The researchers are of the opinion that the research on this topic is incomplete but extremely necessary.

Ključne riječi

drugs; meta-analysis; epidemiological studies

Hrčak ID:

191061

URI

https://hrcak.srce.hr/191061

Datum izdavanja:

20.12.2017.

Podaci na drugim jezicima: hrvatski

Posjeta: 6.677 *

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