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Pre-symptomatic diagnostics of medullary thyroid carcinoma using r-DNA methods

Koraljka Gall-Trošelj


Puni tekst: engleski pdf 2.060 Kb

str. 23-27

preuzimanja: 233

citiraj

Puni tekst: hrvatski pdf 2.060 Kb

str. 23-27

preuzimanja: 582

citiraj


Sažetak

The distinction of sporadic from inherited medullary thyroid carcinomas (MTCs) is of clinical importance because of the differences in prognosis and the need for family screening for genetic counselling required in the latter. Germline mutations in the ret proto-oncogene are associated with multiple endocrine neoplasia type 2. Somatic point mutations in the same gene are identified in a subset of sporadically occurring MTCs. The methods of molecular medicine are suitable to distinguish heritable from non-heritable MTCs and identify asymptomatic individuals at risk.

Ključne riječi

medullary thyroid carcinoma; DNA analysis; pre-symptomatic diagnostics

Hrčak ID:

192071

URI

https://hrcak.srce.hr/192071

Datum izdavanja:

1.12.1998.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.525 *