Medicina, Vol. 54 No. 1, 2018.
Izvorni znanstveni članak
https://doi.org/10.21860/medflum2018_192885
Could smoking increase the risk for metabolic syndrome among patients with schizophrenia in a Croatian population?
Sergej Nadalin
orcid.org/0000-0002-1601-9094
; Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Jelena Rebić
; Klinika za psihijatriju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Klementina Ružić
; Klinika za psihijatriju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Eni Perčić
; Fakultet zdravstvenih studija Sveučilišta u Rijeci, Rijeka, Hrvatska
Vesna Šendula Jengić
; Psihijatrijska bolnica Rab, Rab, Hrvatska
Alena Buretić-Tomljanović
; Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Sažetak
Aim: Schizophrenia is associated with a high rate of nicotine dependence as well as with a high prevalence of metabolic syndrome. However, little is known about the influence of smoking on components of metabolic syndrome in this illness. In the current study we aim to investigate whether, and to what extent, smoking may contribute to plasma lipid and glucose concentrations and body mass index (BMI) values in Croatian patients with schizophrenia.
Patients and methods: Our study comprised 263 chronically ill patients (males/females: 139/124) who met criteria for schizophrenia, according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Smokers were defined as individuals who smoked more than one cigarette each day for more than one year, and nonsmokers were defined as those who had smoked fewer than 100 cigarettes during their lifetime.
Results: Although an elevated smoking rate was detected (males: 70.5%; females: 60.5%), we did not observe significant differences in plasma lipid and glucose concentrations and BMI values between male smokers and nonsmokers; whereas, among females, we revealed variations only in triglyceride concentrations according to the smoking status. In particular, triglyceride concentrations were slightly higher among female smokers than among nonsmoking females (1.6 ± 0.7 vs. 1.3 ± 0.5; F = 4.25, P = 0.042). However, multiple regression analysis revealed that only age was a significant predictor of triglyceride values in females (β = 0.41, R2 change = 0.171, P < 0.001), whereas the influence of smoking on triglyceride values as well as on other investigated metabolic parameters was not statistically significant, neither among males, nor among females (P > 0.05).
Conclusion: According to our results, we may conclude that smoking does not influence plasma lipid and glucose concentrations and BMI values neither among male nor among female patients with schizophrenia.
Ključne riječi
body mass index; glucose; lipids; schizophrenia; smoking
Hrčak ID:
192885
URI
Datum izdavanja:
1.3.2018.
Posjeta: 2.599 *