Skoči na glavni sadržaj

Kineziologija, Vol. 50. No. Supplement 1., 2018.

Pregledni rad

The impact of physical exercise on the skeletal muscle clock genes

Gerardo Gabriel Mirizio orcid id orcid.org/0000-0003-4774-3445 ; Postgraduate Program on Physical Education, Universidade Católica de Brasília, DF, Brazil
Rodolfo Soares Mendes Nunes ; Graduate Program on Physical Education, Unopar, Maringá, PR, Brazil
Ana Lucia Castillo Figueroa ; Diabetes and Obesity Laboratory, IDIBAPS, Barcelona, Spain
Irineu de Sousa Junior ; Postgraduate Program on Physical Education, Universidade Católica de Brasília, DF, Brazil
Aparecido Pimentel Ferreira orcid id orcid.org/0000-0002-0069-1206 ; Postgraduate Program on Physical Education, Universidade Católica de Brasília, DF, Brazil
Elaine Vieira orcid id orcid.org/0000-0002-0621-9367 ; Postgraduate Program on Physical Education, Universidade Católica de Brasília, DF, Brazil

Puni tekst: engleski pdf 1.094 Kb

str. 5-18

preuzimanja: 787

citiraj

Sažetak

The most important circadian synchronizer is the central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The rhythmicity of all organs is achieved by molecular clock gene expression in the central clock and the pace is reached through neuronal and humoral signals to peripheral tissues. Skeletal muscle is one of the peripheral organs that express clock and clock controlled genes (CCGs) which display circadian rhythmicity. Recent studies have pointed out the role of clock genes in skeletal muscle function and
metabolism. The expression of clock genes in skeletal muscle might be altered by several external stimuli and also by different diseases. Physical exercise is a nonphotic stimulus that can realign the skeletal muscle circadian system to the central clock, imposing a new rhythm at the organism level. This effect may be crucial to prevent or ameliorate diseases and disorders caused by disruptions of circadian rhythms. In this review, we discuss the role of clock genes in skeletal muscle function and the importance of physical exercise as a potent synchronizing stimulus for the skeletal muscle molecular clock.

Ključne riječi

clock genes; physical exercise; skeletal muscle

Hrčak ID:

193326

URI

https://hrcak.srce.hr/193326

Datum izdavanja:

31.3.2018.

Posjeta: 1.497 *