Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?

Skoči na glavni sadržaj

Arhiv za higijenu rada i toksikologiju, Vol. 56 No. 2, 2005.

Stručni rad

Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?

Simona Bussi
Alberto Morisetti

Puni tekst: engleski pdf 73 Kb

str. 157-160

preuzimanja: 2.444

APA 6th Edition

Bussi, S. i Morisetti, A. (2005). Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arhiv za higijenu rada i toksikologiju, 56 (2), 157-160. Preuzeto s https://hrcak.srce.hr/144

MLA 8th Edition

Bussi, Simona i Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju, vol. 56, br. 2, 2005, str. 157-160. https://hrcak.srce.hr/144. Citirano 31.12.2024.

Chicago 17th Edition

Bussi, Simona i Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju 56, br. 2 (2005): 157-160. https://hrcak.srce.hr/144

Harvard

Bussi, S., i Morisetti, A. (2005). 'Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?', Arhiv za higijenu rada i toksikologiju, 56(2), str. 157-160. Preuzeto s: https://hrcak.srce.hr/144 (Datum pristupa: 31.12.2024.)

Vancouver

Bussi S, Morisetti A. Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arh Hig Rada Toksikol. [Internet]. 2005 [pristupljeno 31.12.2024.];56(2):157-160. Dostupno na: https://hrcak.srce.hr/144

IEEE

S. Bussi i A. Morisetti, "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?", Arhiv za higijenu rada i toksikologiju, vol.56, br. 2, str. 157-160, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/144. [Citirano: 31.12.2024.]

Sažetak

The margin of safety of a drug is defined as the ratio between toxicity in animals and safety in humans. For intravascular contrast media, the margin of safety is traditionally the ratio between LD50 and diagnostic dose, both doses being based on bodyweight. The shift to surface area dramatically reduces this margin to unacceptable values. Toxicokinetics, which relates systemic exposure associated with early toxic signs in animals to plasma level in man, seems the most accurate and predictive criterion.

Ključne riječi

acute toxicity; diagnostic dose; LD50; toxicokinetics

Hrčak ID:

144

URI

https://hrcak.srce.hr/144

Datum izdavanja:

23.5.2005.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.815 *