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Microbial Production of 3-hydroxypropionaldehyde from Glycerol Bioconversion

C. Ulmer
A.P. Zeng

Sažetak

3-Hydroxypropionaldehyde (3-HPA) is of high industrial interest as a new platform intermediate from bioconversion of renewable materials because it can be converted into a number of large scale commodity chemicals. In this work we studied the production of 3-HPA from bioconversion of glycerol in a two-stage process. In the first stage active biomass is produced. The active biomass is then used for the production of 3-HPA in a second stage by biotransformation with the help of semicarbazide to trap 3-HPA from the culture. First we optimized the conditions for active biomass production for the biotransformation in the second step. By using a fed-batch process with proper feeding of semicarbazide and supplementary addition of active biomass we reached a final concentration of 54 g/l 3-HPA with a yield of 97 %mol/mol. This represents the highest 3-HPA concentration and yield reported so far for the microbial production of 3-HPA from glycerol.

Ključne riječi

3-Hydroxypropionaldehyde; glycerol; Klebsiella pneumoniae; biotransformation

Hrčak ID:

18320

URI

https://hrcak.srce.hr/18320

Datum izdavanja:

29.12.2007.

Posjeta: 1.813 *