Izvorni znanstveni članak

Imidazoles II. Synthesis and Some Pharmacolog-ical Properties of Nitroimidazol-1-yl-ethylsulphonamides

Z. Crnić ; PLIVA, Pharmaceutical, Chemical, Food and Cosmetic Industry, Research Institute, I. L. Ribara 89, 47000 Zagreb , Yugoslavia
B. Glunčić ; PLIVA, Pharmaceutical, Chemical, Food and Cosmetic Industry, Research Institute, I. L. Ribara 89, 47000 Zagreb , Yugoslavia

Sažetak

Starting from 1-aminoethyl-5-nitroimidazoles 9-12, and their
4-nitro isomers 13-16, sulphonamido derivatives 17-40 and 45-68
were prepared by condensation with various arylsulfonylchlorides. ·
Para-amino derivatives 41-44 and 69-72 were obtained by acidic
hydrolysis of the intermediary para-acet.amido derivatives 22, 28,
34, 40, 50, 56, 62, and 68. Compounds 2 and 24-26 exhibited antitrichomonal
activity comparable to that of metronidazole, while
the bacteriostatic activity of compounds 2, 6, 10, 23-28, 42, 55, 56,
and 70 was comparable to that of sulfaphenazole.

Ključne riječi

Hrčak ID:

194340

URI

https://hrcak.srce.hr/194340

Datum izdavanja:

20.7.1981.

Posjeta: 657 *