Izvorni znanstveni članak

https://doi.org/10.5562/cca3261

Ultrasound-assisted and Efficient Knoevenagel Condensation Reaction Catalyzed by Silica Sodium Carbonate Nanoparticles

Yaghoub Pourshojaei orcid.org/0000-0002-6994-7361 ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Maryam Nikzad ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Khalil Eskandari orcid.org/0000-0002-2919-7324 ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Mohammad-Hossein Darijani ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abdolreza Hassanzadeh ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Ehsan Faghih-Mirzaei ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Ali Asadipour ; Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran

Sažetak

An efficient and ultrasound-assisted route to the synthesis of arylidene malononitriles/methylciano- or ethylciano acetates in a one-pot reaction catalyzed by silica sodium carbonate nanoparticles (SSC NPs) is described. In this reaction, SSC NPs demonstrated high efficiency as catalyst to obtain target products. By this achievement, a wide range of α,β-unsaturated compounds as Knoevenagel condensation products with good to excellent yields are obtained from reaction between numerous arylaldehydes, and malononitrile, methyl cianoacetate or ethyl cianoacetate. Target products which prepared in high yield and high purity can be candidate as important biologically active molecules. This method is an easy, cheap, rapid and highly efficient for the synthesis of desired products. In addition, capability of catalyst to separate from reaction mixture and reuse in further runs and being compatible with green chemistry are considered as other advantages of this procedure. All products were deduced from their FT-IR and FT-NMR spectroscopic and elemental analysis data.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi

nanocatalyst; silica sodium carbonate nanoparticles; Knoevenagel reaction; active methylene compounds

Hrčak ID:

194864

URI

https://hrcak.srce.hr/194864

Datum izdavanja:

2.1.2018.

Posjeta: 1.652 *