Izvorni znanstveni članak
Comparative analysis of testicular tumors in men and dogs in the Republic of Croatia
Marko Hohšteter
orcid.org/0000-0001-8844-2660
; Zavod za veterinarsku patologiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Branka Artuković
; Zavod za veterinarsku patologiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Marijana Ćorić
; Klinički bolnički centar Zagreb, Klinički zavod za patologiju i citologiju, Zagreb, Hrvatska
Krešimir Severin
; Zavod za sudsko i upravno veterinarstvo, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Andrea Gudan Kurilj
; Zavod za veterinarsku patologiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Ana Beck
; Zavod za veterinarsku patologiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Ivan-Conrado Šoštarić-Zuckermann
; Zavod za veterinarsku patologiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Željko Grabarević
; Zavod za veterinarsku patologiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
Sažetak
Testicular tumors are among most prevalent tumors in men and dogs. Germ cell tumors have different biological behavior, but are morphologicaly similar and very frequent in both species. Material and methods:Testicles from necropsied dogs and the samples of biopsed canine tumors, from the Faculty of Veterinary Medicine, Zagreb, are analyzed. Analyzed are also samples of biopsed men tumors from the Pathology Depertment, University Hospital Centre Zagreb. Results:Testicular tumors were found in 52% of necropsied, and regarding other biopsed tumors testicular comprised 7% of all biopsed canine tumors. Median age of necropsied dogs with testicular tumors was 10,16 and for biopsed dogs 10,24 years. Human patients developed
testicular tumors at a medium age of 33,35 years. In the necropsied dogs group most frequent were Leydig cell tumors, and in biopsed group most common were seminomas. Additionaly in both groups very frequent were also Sertoli cell tumors, mixed tumors and GCNIS. GCNIS
are additionaly found in 25% of necropsied and 19% of biopsed dog testicles. In the human testicles, most frequently diagnosed were seminomas, embrional carcinomas, teratomas, GCNIS and mixed germ cell tumors. GCNIS as additional alterations were diagnosed in 65%
of human testicular tumors. Performed immunohistochemical analysis showed that investigated markers are useful for differentiation of canine testicular tumors. In dogs, cytokeratin AE1/AE3 showed particularly good results in differentiation of stromal tumor, especially Sertoli cell tumors from the germ cell tumors. c-KIT and PLAP showed higher expression in germ cell tumors, and PLAP showed expression in GCNIS of the dogs. CD 30 was weakly expressed in canine tumors. Discussion and conclusions:Conducted histopatological analyis and application of PLAP proving existance of GCNIS in canine testicles. Expression of c-KIT confirmed that canine seminomas can be, like in human, classified into two groups: c-KIT positive classical seminomas and c-KIT negativne spermatocytic tumors.
Ključne riječi
dog; human; tumor; testis; pathology; immunohistochemistry
Hrčak ID:
195082
URI
Datum izdavanja:
6.3.2018.
Posjeta: 1.288 *