Izvorni znanstveni članak

https://doi.org/10.20471/acc.2017.56.04.18

Bleeding Peptic Ulcer – Tertiary Center Experience: Epidemiology, Treatment and Prognosis

Ivan Budimir ; Division of Gastroenterology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Sanja Stojsavljević ; Division of Gastroenterology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Davor Hrabar ; Division of Gastroenterology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Dominik Kralj ; Division of Gastroenterology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Alen Bišćanin ; Division of Gastroenterology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Lora Stanka Kirigin ; Division of Endocrinology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Mario Zovak ; Department of Surgery, Sestre milosrdnice University Hospital Center, School of Medicine and School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Žarko Babić ; Division of Gastroenterology, Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia
Sven Bohnec ; Gastronterologie, Allgemeine Innere Medizin und Geriatrie, Rems-Murr Klinik Winnenden, Winnenden, Germany
Ivan Budimir Jr ; Magdalena Department of Cardiovascular Diseases, Osijek School of Medicine, Krapinske Toplice, Croatia

Sažetak

The aim of this study was to demonstrate epidemiological, clinical and endoscopic characteristics of acute upper gastrointestinal bleeding (UGIB) with special reference to peptic ulcer bleeding (PUB). The study included 2198 consecutive patients referred to our emergency department due to acute UGIB from January 2008 to December 2012. All patients underwent urgent upper GI endoscopy within 24 hours of admission, and 842 patients diagnosed with PUB were enrolled and prospectively followed-up. The cumulative incidence of UGIB was 126/100,000 in the 5-year period. Two out of five patients had a bleeding peptic ulcer; in total, 440 (52.3%) had bleeding gastric ulcer, 356 (42.3%) had bleeding duodenal ulcer, 17 (2%) had both bleeding gastric and duodenal ulcers, and 29 (3.5%) patients had bleeding ulcers on gastroenteric anastomoses. PUB was more common in men. The mean patient age was 65.9 years. The majority of patients (57%) with PUB were taking agents that attenuate the cytoprotective function of gastric and duodenal mucosa. Rebleeding occurred in 77 (9.7%) patients and 47 (5.9%) patients required surgical intervention. The 30-day morality was 5.2% and 10% of patients died from uncontrolled bleeding and concomitant diseases. In conclusion, PUB is the main cause of UGIB, characterized by a significant rebleeding rate and mortality.

Ključne riječi

Gastrointestinal hemorrhage – epidemiology; Gastrointestinal hemorrhage – therapy; Peptic ulcer hemorrhage – epidemiology; Peptic ulcer hemorrhage – therapy; Endoscopy, gastrointestinal

Hrčak ID:

195453

URI

https://hrcak.srce.hr/195453

Datum izdavanja:

15.12.2017.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.145 *