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The Synthesis of the Fluorescence Probe, 12-(1-Pyrenyl)dodecanoic Acid

B. Katušin-Ražem ; Radiation Laboratory, University of Notre Dame, Notre Dame, Indiana 46556, U .S.A.

Puni tekst: engleski pdf 2.251 Kb

str. 163-166

preuzimanja: 131



The synthesis of the fluorescence probe, 12-(1-pyrenyl)dodecanoic
acid, was accomplished by the Wittig reaction between 1-
-pyrenecarboxaldehyde and 10-methoxycarbonyldecyltriphenylphosphonium
bromide, followed by hydrogenation of the unsaturated
product and hydrolysis of methyl ester. The Wittig reaction was
carried out with sodium methoxide in dimethylformamide, at room
temperature and under a N2 atmosphere. This reacion yielded a
mixture of 530/o trans .and 47-0/0 cis isomers of 12- (l-pyrenyl)-11-
-dodecenoate, as determined . by pulsed Fourier transform NMR

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