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https://doi.org/10.2478/acph-2018-0027

Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats

BLANDINA BERNAL-MORALES orcid id orcid.org/0000-0001-5370-4157 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
GABRIEL GUILLÉN-RUIZ orcid id orcid.org/0000-0003-4428-4706 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
JONATHAN CUETO-ESCOBEDO orcid id orcid.org/0000-0003-1465-012X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
JUAN FRANCISCO RODRÍGUEZ-LANDA orcid id orcid.org/0000-0001-5837-103X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
CARLOS M. CONTRERAS orcid id orcid.org/0000-0002-8471-8989 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México; Unidad Periférica Xalapa, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Neuroetología, Universidad Vera


Puni tekst: engleski pdf 387 Kb

str. 381-388

preuzimanja: 383

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Sažetak

The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. The dose-response curve for diazepam indicated that the 0.5 mg kg–1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications.

Ključne riječi

anxiety, diazepam, weaning rats, elevated plus maze, forced swim, open field test

Hrčak ID:

196040

URI

https://hrcak.srce.hr/196040

Posjeta: 705 *