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https://doi.org/10.2478/acph-2018-0028

Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice

XIAO-MING SI ; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266021, China
YU-HUA TIAN ; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266021, China
SHA-SHA ZHANG ; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266021, China
HUA GAO ; Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, 266021, China
KUN LIU ; Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, Qingdao, 266021, China
JING-YU JIN ; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266021, China


Puni tekst: engleski pdf 465 Kb

str. 361-371

preuzimanja: 345

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Sažetak

The present study is aimed at testing the antidepressant-like effects and probable mechanisms of action of low molecular mass chondroitin sulfate (LMMCS) on depression induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, expressed by a significant decrease in the locomotor activity and sucrose consumption and increased immobility time in the forced swim test. Further, there was a significant reduction of 5-HT level in the hippocampus region of depressed mice. Treatment of mice for four weeks with LMMCS ameliorated significantly both the behavioral and biochemical changes induced by CUMS. These novel results suggest that LMMCS produces an antidepressant-like effect in mice subjected to CUMS, which might be related, at least in part, to the increase of 5-HT concentration in the hippocampus.

Ključne riječi

low molecular mass chondroitin sulfate, chronic unpredictable mild stress, depression, mice, hippocampus, 5-HT

Hrčak ID:

196041

URI

https://hrcak.srce.hr/196041

Posjeta: 656 *