Medicinski vjesnik, Vol. 22 No. (1-2), 1990.
Izvorni znanstveni članak
Patophysiology of erythrocyte sedimentation rate
Zdenko Kovač
Sažetak
Erythrocyte sedimentation rate (ESR) is a simple laboratory test which reflects separation of plasma and blood cells due to gravitation force. Erythrocytes spontaneously form aggregates which contribute to the overall sygmoidal kinetics of sedimentation. Cell aggregation energy is a manifestation of aggregative properties of various plasma constituents. Since many different molecules can influence aggregation, ESR is a nonspecific test, and therefore, correlations to disease processes represent a complex interrelationship. This article reviews our contemporary understanding of the rules and processes underlying erythrocyte sedimentation phenomenology. The text describes relevant theoretical physical laws, morphology and kinetics of ESR. Relevant experimental data concerning the influences of particular factors on sedimentation rate are reviewed. Pathogenesis and clinical significance of sedimentation phenomenology are analysed through complex contributions of the plasma and cell pertubations, which rule the overall sedimentation. Clinical handiness of the test is in its broad scanning reactivity. ESR pertubations reveal the pertubation of a least one of the acting factors. On the other hand, its relative significance in differential diagnosis is minimal. High or low ESR is a common denominator of a general cell aggregation tendency, and therefore it should be considered as a simple monitor of blood changes. For that reason, development of new and more specific diagnostic techniques has not made the test obsolete.
Ključne riječi
erythrocyte sedimentation; phvsiopathoogy
Hrčak ID:
196180
URI
Datum izdavanja:
1.12.1990.
Posjeta: 5.374 *