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Actions of Histrionicotoxin on Acetylcholine Receptors

G. Kato ; Neurobiologie Moleculaire, Institut Pasteur, Paris 75015, France
M. Glavinovic ; Department of Research in Anaesthesia, Mc Gill University, Montreal, Canada
J. Henry ; Department of Research in Anaesthesia, Mc Gill University, Montreal, Canada
K. Krnjevic ; Department of Research in Anaesthesia, Mc Gill University, Montreal, Canada
E. Puil ; Department of Research in Anaesthesia, Mc Gill University, Montreal, Canada
B. Tattrie ; Department of Research in Anaesthesia, Mc Gill University, Montreal, Canada

Sažetak

The effects of histrionicotoxin have been evaluated at the rat
neuromuscular junction, the eel electroplaque and on the central
nervous system of the cat, and have been shown to reduce markedly
the response to acetylcholine or carbamylcholine. This toxin does
not inhibit the binding of acetylcholine to Torpedo membrane
fragments rich in acetylcholine receptor .protein, but rather augments
its affinity for the receptor site. These findings suggest an
accentuation of a desensitization phenomenon or a block of ionic
channels.

Ključne riječi

Hrčak ID:

196635

URI

https://hrcak.srce.hr/196635

Datum izdavanja:

3.12.1975.

Posjeta: 723 *