Medicinski vjesnik, Vol. 21 No. (3), 1989.
Izvorni znanstveni članak
Cimetidine and ranitidine tests: the influence on the basal values of serum gastrin
Darko Kraljik
Ivan Čandrlić
Dubravko Božić
Miroslav Volarić
Sažetak
Investigating the influence of histamine H2 receptor antagonists on the levels of basal serum gastrin (BSG), two modern drugs were used - cimetidine and ranitidine. Two groups of patients with various pathological conditions of the gastrointestinal system were tested with cimetidine. In the first group, 14 patients were given 200 mg of cimetidine i.v. every six hours during 24 hours. The same test with 400 mg of cimetidine was performed with 9 patients of the second group. Contrary to the expectations, the level of BSG in the first group of patients decreased, except in two of them with duodenal ulcer. There is a statistically significant difference for 11 patients of this group suffering from duodenal ulcer (t = 2.26; p<0.025). The decrease of BSG in the second group was not so obvious, but in two patients with pernicious anemia the decrease of BSG was remarkable. These results can be interpreted as the indirect proof of cimetidine influence on G-cells, as well, over H2 or some other receptors. Peroral ranitidine testing, with 150 mg 3 times a day the first day and then twice a day in the next two days, was performed in 13 patients. The levels of BSG were measured within 4 days, every morning after awakening. The results show a slight BSG increase.
Ključne riječi
cimetidine; gastrin; peptic ulcer; ranitidine
Hrčak ID:
196914
URI
Datum izdavanja:
1.12.1989.
Posjeta: 1.421 *