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Surfaces and the Folding of Polypeptide Chains

A. G. Walton ; Case Western Reserve University, Division of Macromolecular Science, Cleveland, Ohio 44106, U.S.A.

Puni tekst: engleski pdf 7.696 Kb

str. 59-66

preuzimanja: 84



An approach to the folding of polypeptide chains is explored
theoretically and compared with experimental data. It appears that
in synthetic chain folded polypeptide crystals, the fold period is
statistically determined by the energetics of nucleation.
The broader question of chain folding in globular proteins is
presented and an equation derived which shows that the fold length
is likely to be a function mainly of the particular fold energy and
the driving free energy derived from long range stabilization forces.

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