Medicinski vjesnik, Vol. 20 No. (4), 1988.
Izvorni znanstveni članak
Values of the serum proteins in the extrahepatic cholestasis in rats
Aleksandar Včev
Ivan Čandrlić
Stjepan Gamulin
Dubravko Božić
Sažetak
In this research the complete obstruction of bile duct in rats has been achieved, in order to observe the influence of extrahepatic cholestasis on the concentration of serum proteins. It has been noted that the extrahepatic cholestasis provokes a continuous fall in the concentrations of total proteins and albumin in serum. The fall of the total proteins in serum is not statistically significant compared to the control concentrations, whereas the fall in albumin becomes statistically significant (P < 0.01) from the seventh day of the cholestasis. The cholestasis has induced changes in the concentration of electrophoretic fractions of serum proteins. A continuous and statistically significant (P < 0.01) fall in albumin fraction has been noted from the seventh day on, which responds to the fall in the absolute albumin concentration in serum. Besides that, a continuous and statistically significant (P < 0.01) increase of beta fraction has been observed from the seventh postoperative day. On the thirtieth day beta and gama globulin fraction merged. The cholestasis has induced manifold increase in the activity of total bilirubin, alkaline phosphatase, gama GT, SGOT and SGPT in serum. Total bilirubin, alkaline phosphatase and gama GT have been rising continuously up to the fourteenth postoperative day, when they have reached the highest concentrations. From that day on, the fall in the concentrations of all three parametres has been noted. Statistically significant (P < 0.05) linear correlations have been found between the concentration of total proteins and the duration of cholestasis (negative), between the total bilirubin concentration and the duration of cholestasis from the third to the fourteenth day as well as between the total protein and albumin concentration in serum. Statistically significant quadratic correlations have also been observed between the duration of cholestasis and total protein concentrations (P < 0.01), albumin (P < 0.01), alcaline phosphatase (P < 0.05) and gama GT in serum (P < 0.01), respectively.
Ključne riječi
extrahepatic cholestasis in rats; serum proteins
Hrčak ID:
197243
URI
Datum izdavanja:
1.12.1988.
Posjeta: 1.432 *