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Effect of Insulin, Epinephrine, Hydrocortisone and ACTH on the Catheptic Activity of Rat Spleen

J. Babnik ; Department of Biochemistry, lnstitut »Jozef Stefan«, Ljubljana, Slovenia, Yugoslavia
D. Lebez ; Department of Biochemistry, lnstitut »Jozef Stefan«, Ljubljana, Slovenia, Yugoslavia

Sažetak

In our experiments under in vivo conditions we followed ·the
response of spleen on injected insulin, epinephrine, hydrocortisone
and ACTH.
Insulin caused a decrease in spleen weight, a decrease of
protein nitrogen and an increase of catheptic activity 30 min. after
application. Afterwards catheptic activity was significantly above
control value in 60 min. (expressed in E. U./g. tissue) although·
decreasing tendency was observed. 30 and 60 min. after epinephrine
application spleen weight and protein nitrogen were increased
whereas catheptic activity remained under the control value (expressed
in E. U./mg.N). After 3 hrs the spleen weight was reduced
(reduced protein nitrogen) whereas catheptic activity was significantly
increased, specially if expressed in E. U./g. tissue. Hydrocortisone
caused a decrease in spleen weight and protein nitrogen.
Catheptic activity was significantly above control value 30 min.
and 3 hrs after application, if expressed in enzyme unit per gram
tissue. Two hours after ACTH administration protein nitrogen was
increased, whereas catheptic activity was under the control value
(expressed in E. U.jmg. N).

Ključne riječi

Hrčak ID:

197520

URI

https://hrcak.srce.hr/197520

Datum izdavanja:

10.2.1971.

Posjeta: 779 *