Pregledni rad
NORMOBARIC HYPEROXIA IN NEUROANESTHESIA
MARTINA MIKLIĆ BUBLIĆ
orcid.org/0000-0002-4471-1117
; Klinički bolnički centar Zagreb, Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Zagreb, Hrvatska
MARIJANA MATAS
; Klinički bolnički centar Zagreb, Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Zagreb, Hrvatska
ANTE SEKULIĆ
; Klinički bolnički centar Zagreb, Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje i Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska
Sažetak
Normobaric hyperoxia is occasionally mentioned in the literature concerning neurosurgical anesthesia. Opinions vary on this subject. Hyperoxia was long related to the potentially harmful influence of reactive oxygen species that are produced during hyperoxia in the amounts greater than the antioxidant capacity, thus causing hyperoxic acute lung injury. Recent research shows that hyperoxia may be benefi cial in treating traumatic brain injury. The main goals in neuroanesthesia are maintaining intracranial pressure and cerebral perfusion pressure while preventing secondary brain injury. Hyperoxia enhances brain tissue oxygenation and brain aerobic metabolism, thus being neuroprotective. Additional benefi t of hyperoxia may be found in the treatment of postoperative pneumocephalus by diminishing postoperative nausea and vomiting, and reducing the incidence of surgical site infections and facilitating their healing, thus providing better patient recovery. Considering the potential benefi ts of normobaric hyperoxia and its possible detrimental effect, additional investigation is needed to clearly defi ne the patient category where hyperoxia may have positive effect on patient outcome.
Ključne riječi
normobaric hyperoxia; neuroanesthesia; neurosurgery; traumatic brain injury; stroke; pneumocephalus; hyperoxic lung injury
Hrčak ID:
197901
URI
Datum izdavanja:
3.4.2018.
Posjeta: 1.606 *