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Importance of investigation of bile salts and their derivatives as building blocks of supramolecular hosts for the purpose of treatment

Tea Mihelj
Vlasta Tomašić


Puni tekst: hrvatski pdf 18.853 Kb

str. 103-120

preuzimanja: 138

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Puni tekst: engleski pdf 18.853 Kb

str. 103-120

preuzimanja: 142

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Sažetak

This article reports a variety of physico-chemical methods and techniques that have been used in the research of native, model bile systems. Interactions of the anionic biological surfactant, odium cholate and synthetic single- and double- chained surfactants, as well as sodium cholate and metal ions with increasing charges, were examined. These systems provide new insight into the complex processes of precipitation, vesiculation and gelation, and better understanding of those that take place in the living organism. The dependence of molecules of bile salts and their analogues on molecular interactions, molecular packing and properties of crystalline materials is established, so they can be utilized as supramolecular receptors for various types of guest molecules and ions, and for the design of novel materials. Such researches find their physiological (in diagnosis or developing new pharmacological applications) or pathophysiological relevance (in preventing harmful reactions, such as precipitation), and show close relationship between medicine and biotechnology, organic, macromolecular, inorganic and physical chemistry.

Ključne riječi

Surface-active agents – analysis, chemistry, diagnostic use, pharmacology, physiology, therapeutic use; Bile acids and salts – analogs and derivatives, analysis, chemistry, diagnostic use, metabolism, pharmacology, physiology, therapeutic use

Hrčak ID:

198048

URI

https://hrcak.srce.hr/198048

Datum izdavanja:

1.12.2011.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.079 *