Pregledni rad
Colorectal cancer - pathohistological standards
Sanda Šitić
; Department for Pathology Ljudevit Jurak, Unit for Oncological Pathology, Sestre milosrdnice Universitiy Hospital Center, Zagreb, Croatia
Marija Milković-Periša
; Department for Pathology Ljudevit Jurak, Unit for Oncological Pathology, Sestre milosrdnice Universitiy Hospital Center, Zagreb, Croatia
Iva Bobuš-Kelčec
; Department for Cytology, Sestre milosrdnice Universitiy Hospital Center, Zagreb, C
Tajana Silovski
; Department of Medical Oncology, Sestre milosrdnice Universitiy Hospital Center, Zagreb, Croatia
Hrvoje Silovski
; Department for Gastrointestinal Surgery, Universitiy Hospital Center Zagreb, Zagreb, Croatia
Tomislav Orešić
; Department for Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice Universitiy Hospital Center, Zagreb, Croatia
Sažetak
Colorectal carcinoma is the third most common cancer site in Croatia, according to the data published by the The Croatian National Cancer Registry. In the last decade, the knowledge about pathogenesis and molecular background of colorectal carcinoma has increased dramatically. More than 90% of colorectal carcinomas are adenocarcinomas originating from epithelial cells of the colorectal mucosa. Tumor staging is the most important prognostic predictor of clinical outcome for patients with colorectal carcinoma. The TNM classification has nowdays replaced other classification systems (Dukes,
Astler-Coller) and serves as golden standard in everyday practise.In 2012, 5th Croatian Congress for Pathology resulted in uniform standard for pathologic reporting for all cancer sites. The future for colorectal cancer prognosis and therapy is to discover new molecular subtypes of colorectal cancer which represents the future of personalized oncology and will guide drug-development strategies.
Ključne riječi
colorectal cancer; TNM classification; personalized oncology
Hrčak ID:
200574
URI
Datum izdavanja:
27.12.2013.
Posjeta: 1.430 *