Skoči na glavni sadržaj

Pregledni rad

https://doi.org/10.21857/94kl4cx7qm

Stem cell heterogeneity – a prerequisite for successful (dental) regeneration

Maja Sabalić ; Centre for Craniofacial and Regenerative Biology, King’s College London, Dental Institute, London, United Kingdom
Paul T. Sharpe ; Centre for Craniofacial and Regenerative Biology, King’s College London, Dental Institute, London, United Kingdom


Puni tekst: engleski pdf 332 Kb

str. 51-59

preuzimanja: 231

citiraj


Sažetak

Advancements in regenerative dentistry could soon equip dentists with tools to regenerate dental pulp and other tissues. Developing effective regenerative therapies has proven to be a challenging task due to the complexity of tooth structure, functional and aesthetic requirements, safety and patient factors. However, recent studies looking at behaviour of adult mesenchymal stem cells in murine teeth in vivo offer new insights for development of translational approaches for tissue regeneration. Molecular heterogeneity within the mesenchymal stem cell (MSC) niche has recently been studied in vivo using genetic lineage tracing and single-cell RNA sequencing. The role of an established, Thy1 (CD90)-marked sub-population is studied in homeostasis and following stimulation of increased growth of mouse incisors. Recent results suggest that this sub-population plays a specific role in rapid growth, during development as well as in stimulated increased growth and can be replenished by activation of dormant stem cells. These findings have implications for development of new, targeted regenerative therapies harnessing the potential of tissue-resident stem cells in a surgical intervention or non-surgical, molecular signal delivery approach.

Ključne riječi

mesenchymal stem cells, adult stem cells, regenerative dental medicine, dental pulp

Hrčak ID:

201078

URI

https://hrcak.srce.hr/201078

Podaci na drugim jezicima: hrvatski

Posjeta: 641 *