Izvorni znanstveni članak

https://doi.org/10.20471/acc.2018.57.01.10

Presence of Helicobacter Pylori in the Stomach and Laryngeal Mucosal Linings in Patients with Laryngeal Cancer

Ivana Pajić Matić orcid.org/0000-0002-5778-6695 ; Department of ENT and Head and Neck Surgery, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia
Davor Jelić ; Department of Internal Medicine, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia
Ivo Matić ; Department of Anesthesia and Resuscitation, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia
Siniša Maslovara ; Department of ENT and Head and Neck Surgery, Vukovar General Hospital, Vukovar, Croatia
Tihana Mendeš ; Department of ENT and Head and Neck Surgery, Vukovar General Hospital, Vukovar, Croatia

Sažetak

Helicobacter (H.) pylori is the cause of one of the most common chronic bacterial infections in humans. Risk factors for the development of laryngeal cancer are cigarette smoke, alcohol, and human papillomavirus. Several papers report on H. pylori isolated in tooth plaque, saliva, middle ear and sinuses. Many articles describe the presence of H. pylori in laryngeal cancer cases, however, without noting the possible source of infection, i.e. stomach or oral cavity. The aim of this study was to determine which patients and to what extent simultaneously developed H. pylori colonization in the stomach and the larynx. Prospective examinations were performed in 51 patients with laryngeal squamous cell carcinoma. The study group included patients with laryngeal squamous cell carcinoma histopathologically confirmed by two independent pathologists. The patients underwent fiber esophagogastroduodenoscopy with tumor tissue biopsy. Laryngeal and gastric biopsies were examined by histologic staining technique for histopathologic detection of H. pylori and with DNA analyses using the standardized fluorescent ABI Helicobacter plus-minus PCR assay. Laryngeal carcinoma patients showed positive H. pylori test results simultaneously in the laryngeal and stomach areas, implying H. pylori transmission from the stomach to the laryngeal area. In addition, H. pylori positive test results along with negative H. pylori results in the stomach region were also recorded, suggesting a possible bacteria migration from the oral cavity. In conclusion, H. pylori was found in the area of laryngeal carcinoma, and its migration appeared likely to occur both upwards (from the stomach to the mouth) and downwards (from the oral cavity to the stomach).

Ključne riječi

Helicobacter pylori; Bacterial infections; Laryngeal neoplasms; Smoking; Papillomaviridae; Endoscopy, digestive system

Hrčak ID:

201836

URI

https://hrcak.srce.hr/201836

Datum izdavanja:

1.3.2018.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.531 *