Izvorni znanstveni članak
https://doi.org/10.2478/aiht-2018-69-3096
Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids
Slavica Vučinić
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Vesna Kilibarda
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Snežana Đorđević
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Dragana Đorđević
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Nataša Perković-Vukčević
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Gordana Vuković-Ercegović
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Biljana Antonijević
; University of Belgrade Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”, Belgrade, Serbia
Marijana Ćurčić
; University of Belgrade Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”, Belgrade, Serbia
Evica Antonijević
; University of Belgrade Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”, Belgrade, Serbia
Gordana Brajković
; National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia
Sažetak
A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea, vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as “Biljni tamjan” (herbal incense), “Beli slez”, and “Rainbow Special” and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHMICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.
Ključne riječi
chromatography; early warning system; herbal incense; new psychoactive substances; rainbow special; spectrometry
Hrčak ID:
202283
URI
Datum izdavanja:
27.6.2018.
Posjeta: 1.380 *