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New Aspect of the in Vitro Metabolism of Some Biogenic Amines

S. Iskrić ; Tracer Laboratory, Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia
S. Kveder ; Tracer Laboratory, Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia

Puni tekst: engleski pdf 5.399 Kb

str. 233-237

preuzimanja: 78



Tryptamine, 5-methoxytryptamine, tyramine, histamine, octopamine,
dopamine, and noradrenaline were incubated with the
»nuclear fraction« of rat liver homogenate. The first four amines
were also incubated with rat liver slices. The incubation mixtures
were examined by paper chromatography. All substrates were completely metabolised by both tissue preparations except histamine
which was left unchanged. After the incubation with the nuclear
fraction the major metabolftes were always the corresponding
arylaldehyde and aryl carboxylic acid having one C-atom less in
the side chain than the substrate. Liver slices metabolised the
amines to the corresponding aryl acetic acids. These two metabolic
pathways, which are both initiated by monoamine oxidase, are

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