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The Biological Activity and Synthesis of Royal Jelly Acid

Robert Robinson

Puni tekst: engleski pdf 4.747 Kb

str. 119-122

preuzimanja: 139



In the issue of Nature that appeared on May 2nd, 1959 (183, 1270) G. F. Townsend, J. F . Morgan, and B. Hazlett published an important paper showing that the Royal Jelly of Bees (the food of queen larvae, produced in the mandibular glands of worker bees) inhibited the development of transplantable leukaemia and three varieties of ascitic tumours in mice. The main fatty acid of Royal J elly was isolated by Townsend and Lucas in 1940 1 and later shown by Butenandt and Rembold2 to be 10-hydroxydec-2-enoic acid, HOCHiCH2) G CH:CH · C02H. There is about 30/o of this substance in Royal Jelly and its biological activity in the above-mentioned sense was found to be from 20 to 100 times as great. H ence this fatty acid is the active constituent.

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