Izlaganje sa skupa

MRI IN EVALUATION OF INFLAMMATORY MYOPATHY

Jiří Vencovský
Kateřina Kubínová

Sažetak

Background: MRI of skeletal muscles has been widely used to assess several types of myopathies, including inherited and acquired muscle diseases.
Objectives: To describe current possibilities in use of MRI in diagnostics and assessment of idiopathic inflammatory myopathies (IIMs).
Methods: T2 weighted images with fat suppression (T2W/FS) or short tau inversion recovery (STIR) sequence with long time to echo (TE) and T1 weighted images were used to evaluate inflammatory changes (STIR) and muscle atrophy or fat substitution (T1). Simple scoring system was used for correlative studies with histopathological changes. New and more elaborate system for scoring of MR scans was developed and used to evaluate longitudinal images during the therapeutic study.
Results: Muscle biopsy guided by positive MRI finding contains significantly more inflammatory cells than the biopsy taken from MRI identified non-affected sites. However, even in parts of muscles, which look unaffected on MR scan, important numbers of the inflammatory cells can be found. It is mainly the signal intensity in MR scan, which is associated with disease activity in the acute presentation of IIMs. Longitudinal follow-up of patients with IIMs showed significant reduction of signal intensity in number of muscles when using new detailed scoring method.
Conclusions: Muscle MRI is a useful method to guide the biopsy site in IIMs. Scoring system that uses semiquantitative assessment of individual muscles is sensitive for evaluation of improvement during the treatment. No universal scoring method has been validated and accepted so far for evaluation of inflammation and atrophic changes during IIMs. Developmnet of standard recommendations for muscle MRI assessment in IIMs is very much needed.
References:
1. Tomasová Studýnková J, et al. Rheumatology (Oxford) 2007,46:1174–79.
2. Kubínová K, et al. Curr Opin Rheumatol 2017;29:623–31.
3. Kubínová K, et al. Clin Exp Rheumatol 2018;36 Suppl 114(5):74–81.

Ključne riječi

Hrčak ID:

210536

URI

https://hrcak.srce.hr/210536

Datum izdavanja:

5.12.2018.

Posjeta: 703 *