Acta clinica Croatica, Vol. 57. No. 4., 2018.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2018.57.04.06
RET Expression and Its Correlation with Clinicopathologic Data in Papillary Thyroid Carcinoma
Ante Punda
; Department of Nuclear Medicine, Split University Hospital Centre, Split, Croatia
Vladimir Bedeković
; Department of ENT, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ana Barić
; Department of Nuclear Medicine, Split University Hospital Centre, Split, Croatia
Mirko Kontić
; Department of ENT, Split University Hospital Centre, Split, Croatia
Zaviša Čolović
; Department of ENT, Split University Hospital Centre, Split, Croatia
Lucija Vanjaka Rogošić
; Dermatovenereology Private Surgery, Split, Croatia
Hrvoje Punda
; Department of Diagnostic and Interventional Radiology, Split University Hospital Centre, Split, Croatia
Nenad Kunac
; Department of Pathology, Forensic Medicine and Cytology, Split University Hospital Centre, Split, Croatia
Leo Grandić
; Department of Surgery, Split University Hospital Centre, Split, Croatia
Valdi Pešutić Pisac
; Department of Pathology, Forensic Medicine and Cytology, Split University Hospital Centre, Split, Croatia
Sažetak
The purpose of this study was to analyze the possible prognostic value of RET mutation in papillary thyroid carcinoma and its incidence in the past few decades in our population, due to the increasing incidence of papillary thyroid carcinoma. The present study included 180 patients operated for papillary thyroid carcinoma. The clinical and histopathologic characteristics were analyzed. Paraffin sections of the selected histologic slides were cut again and immunohistochemically stained by the Clone 3F8 P (HIER) from Novocastra (Vision Bio Systems Europe, Newcastle upon Tyne, UK) monoclonal antibody to RET oncoprotein. Univariate analysis indicated sex (p=0.01), histologic subtype (p=0.075) and capsular invasion (p=0.010) to be statistically significant predictors of lymph node metastases, whereas age (p=0.796), tumor size (p=0.556) and intraglandular dissemination (p=0.131) showed no such correlation. The presence of RET mutation (p=0.704) was not a statistically significant predictor of the tumor metastasizing potential. RET mutation (p=0.500) showed no statistically significant correlation with papillary thyroid carcinoma classifed into prognostic groups according to clinicopathologic features either. RET mutation was detected in 30% of 180 papillary thyroid carcinomas. This is the first large study demonstrating that RET mutation incidence in papillary thyroid carcinoma in Croatian population is consistent with the classic distribution of sporadic cases, despite the increased prevalence of papillary thyroid carcinoma in the past few decades.
Ključne riječi
Mutation; Thyroid cancer, papillary; Chernobyl nuclear accident; Lymphatic metastasis; Radiation
Hrčak ID:
217814
URI
Datum izdavanja:
1.12.2018.
Posjeta: 1.641 *