Medicus, Vol. 12 No. 2_Spolne bolesti, 2003.
Pregledni rad
Chlamydia trachomatis and Neoplasms of the Female Genital Apparatus
Goran Vujić
Sažetak
In recent times is intensively investigated the
connection of Chlamydia trachomatis as an etiological factor in
the occurrence of preinvasive lesions and genital carcinoma in
women. In the article presents the most important data from literature.
The frequency of C. trachomatis endocervical infection
is significantly higher in women with preinvasive lesions of the
uterine cervix. During 26 years of follow up in the samples of
cytological smears and biotopic materials DNA, C. trachomatis
has been proven by PCR method significantly more often in
women with cervical carcinoma than in women comprising the
control group. The C. trachomatis infection frequency is significantly
higher in women with HPV infection. There is the connection
between chlamydial and HPV infections in the occurrence
of cervical intraepithelial neoplasms (CIN). In the pathogenesis
of CIN lesions, besides HPV infection, other mechanisms
are probably included as well, for example C. trachomatis
infection. C. trachomatis is a possible co-factor in the induction
of preinvasive lesions of the uterine cervix in the HPV
induced occurrence, but not the promoter of the higher stages
of the diseases. Serotype G and simultaneous presence of several
C. trachomatis serotypes are significantly more frequent in
women with cervical carcinoma. What is the real pathogenic
effect of chlamydial infection upon the occurrence of preinvasive
lesions and cervical carcinoma will be shown by further
studies.
Ključne riječi
Chlamydia trachomatis; cervical intraepithelial neoplasm; uterine cervix cancer
Hrčak ID:
20572
URI
Datum izdavanja:
7.10.2003.
Posjeta: 2.063 *