Psychiatria Danubina, Vol. 31 No. 1, 2019.
Original scientific paper
https://doi.org/10.24869/psyd.2019.43
NEUROCOGNITIVE PROFILES OF PATIENTS WITH THE FIRST EPISODE OF PSYCHOSIS AND SCHIZOPHRENIA DO NOT DIFFER QUALITATIVELY: A NESTED CROSS-SECTIONAL STUDY
Dina Bosnjak Kuharic
; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Porin Makaric
; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Ivana Kekin
; Department of Psychiatry, Zagreb University Hospital Centre, Zagreb, Croatia
Zarko Bajic
; Biometrika Healthcare Research, Zagreb, Croatia
Maja Zivkovic
; Department of Psychiatry, Zagreb University Hospital Centre, Zagreb, Croatia
Aleksandar Savic
; University Psychiatric Hospital Vrapce, Zagreb, Croatia; Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia
Drazenka Ostojic
; University Psychiatric Hospital Vrapce, Zagreb, Croatia; Faculty of Law, University of Zagreb, Zagreb, Croatia
Vlado Jukic
; University Psychiatric Hospital Vrapce, Zagreb, Croatia; Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia
Martina Rojnic Kuzman
; Department of Psychiatry, Zagreb University Hospital Centre, Zagreb, Croatia; Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Background: The aim of study was to analyze neurocognitive profiles in patients with first-episode psychosis (FEP) and patients with schizophrenia (SCH), and their correlations with other clinical features.
Subjects and methods: We performed a multicentric cross sectional study including 100 FEP and 100 SCH recruited from three Croatian hospitals during 2015-2017. Assessment included a set of neurocognitive tests, psychiatric scales and self-reporting questionnaires. The main analysis was done by multigroup latent profile analysis.
Results: Multigroup latent profile analysis resulted in three structurally equivalent neurocognitive profiles ("Best", "Medium", "Worst"), with differences in the severity of neurocognitive deficits measured with successfulness in solving domain specific tasks. The "Best" profile was statistically significantly more prevalent in FEP and "Worst" profile in the SCH. Negative symptom score was the highest in patients with the "Worst" profile and the lowest among those with the "Best" profiles.
Conclusions: Differences in neurocognitive profiles between FEP and SCH appear to be quantitative rather than qualitative nature, possibly reflecting a specific trait of illness that may progress over time. Defining neurocognitive profiles from the first episode of psychosis could help in tailoring individualized treatment options with focus on neurocognitive and negative symptoms and possible influence on patients' overall clinical outcome.
Keywords
neurocognitive impairment; neurocognitive profile; psychotic disorders; first-episode psychosis; schizophrenia
Hrčak ID:
222384
URI
Publication date:
4.4.2019.
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