Veterinarski arhiv, Vol. 89 No. 4, 2019.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.0272
Supplementation of a supranutritional dose of zinc sulfate and heat killed Bacillus firmus in early weanling pig diet: the effect on growth, neutrophil function and inflammatory cytokines
Ujjwal K. De
; Division of Medicine, Indian Veterinary Research Institute, Izatnagar Uttar Pradesh, India
Reena Mukherjee
; Division of Medicine, Indian Veterinary Research Institute, Izatnagar Uttar Pradesh, India
Gyanendra K. Gaur
; Livestock Production and Management Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
Ashok K. Verma
; Division of Animal Nutrition, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
Sameer Shrivastava
; Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
Chandan Prakash
; Division of Animal Health, ICAR-Central Sheep and Wool Research Institute, Avikanaga, Rajasthan, India
Sukdeb Nandi
; CADRAD, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
Med R. Verma
; Division of Livestock Economics, Statistics and Information Technology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
Sažetak
The objective of the study was to investigate the effect of supplementation of a supranutritional dose of zinc sulfate (ZnSO4) and Bacillus firmus derived bio-response modifier (BRM) on growth, blood neutrophil functions, pro-inflammatory and anti-inflammatory cytokine responses in early weanling piglets. In total, 45 piglets (age of 19.25 ± 0.84 days) were randomly divided into five groups: I (basal diet only), II (basal diet supplemented with ZnSO4), III (basal diet supplemented with BRM), IV (basal diet supplemented with ZnSO4 plus BRM) and V (basal diet without weaning from dam). The production of myeloperoxidase (MPO) and superoxide anion (O2-), and the concentration of transforming growth factor-β1 (TGF-β1) were markedly reduced, whereas the concentrations of intercellular adhesion molecule 1 (ICAM1), and monocyte chemoattractant protein 1 (MCP1) were significantly (P<0.05) increased in piglets during the post-weaning period. The neutrophil functions did not improve until day 7 of weaning (P>0.05) but a marked increase (P<0.05) in ICAM1, MCP1 and a decrease in TGF-β1 concentrations were observed up to days 14 and 7, respectively, in piglets of groups II and III. However, the addition of BRM plus ZnSO4 in the basal diet improved MPO (day 2) and O2- (day 7) without any significant alterations in growth and cytokine concentrations in group IV piglets. Finally, it is concluded that the addition of BRM plus ZnSO4 to the diet stimulates the innate immunity of weaner piglets compared to ZnSO4 or BRM alone. The findings of the study will definitely help to formulate effective dietary management practice for early weanling piglets in swine herds.
Ključne riječi
Bacillus firmus; cytokine; piglet; weaning; zinc sulfate
Hrčak ID:
225750
URI
Datum izdavanja:
30.9.2019.
Posjeta: 1.054 *