Croatica Chemica Acta, Vol. 92 No. 2, 2019.
Pregledni rad
https://doi.org/10.5562/cca3556
Advances in Desmuramyl Peptide Research
Rosana Ribić
orcid.org/0000-0001-7611-538X
; University North, University Center Varaždin, Jurja Križanića 31b, HR-42000 Varaždin, Croatia
Marija Paurević
; Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Ulica cara Hadrijana 8/A, HR-31000 Osijek, Croatia
Srđanka Tomić
; University of Zagreb, Faculty of Science, Department of Chemistry, Horvatovac 102a, HR-10000 Zagreb, Croatia
Sažetak
Immune adjuvants are added to vaccines in order to enhance the immune response to an antigen. Muramyl dipeptide,
N-acetylmuramyl-L-alanyl-D-isoglutamine, is the smallest structural unit of peptidoglycans showing the immunostimulating activity. Muramyl dipeptide analogues without the hydrophilic N-acetylmuramyl moiety are called desmuramyl peptides. Here, we provide review of desmuramyl peptides which were synthesized in order to improve the pharmacological properties of parent muramyl dipeptide, including our results regarding adamantane containing derivatives. Approach for future design of novel immunostimulators based on multiple pathogen recognition receptor activation was also considered.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ključne riječi
adjuvant; desmuramyl peptides; immunostimulation; pathogen recognition receptors
Hrčak ID:
226603
URI
Datum izdavanja:
29.7.2019.
Posjeta: 1.376 *