Skoči na glavni sadržaj

Pregledni rad

https://doi.org/10.5562/cca3556

Advances in Desmuramyl Peptide Research

Rosana Ribić orcid id orcid.org/0000-0001-7611-538X ; University North, University Center Varaždin, Jurja Križanića 31b, HR-42000 Varaždin, Croatia
Marija Paurević ; Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Ulica cara Hadrijana 8/A, HR-31000 Osijek, Croatia
Srđanka Tomić ; University of Zagreb, Faculty of Science, Department of Chemistry, Horvatovac 102a, HR-10000 Zagreb, Croatia


Puni tekst: engleski pdf 1.899 Kb

str. 153-161

preuzimanja: 464

citiraj


Sažetak

Immune adjuvants are added to vaccines in order to enhance the immune response to an antigen. Muramyl dipeptide,
N-acetylmuramyl-L-alanyl-D-isoglutamine, is the smallest structural unit of peptidoglycans showing the immunostimulating activity. Muramyl dipeptide analogues without the hydrophilic N-acetylmuramyl moiety are called desmuramyl peptides. Here, we provide review of desmuramyl peptides which were synthesized in order to improve the pharmacological properties of parent muramyl dipeptide, including our results regarding adamantane containing derivatives. Approach for future design of novel immunostimulators based on multiple pathogen recognition receptor activation was also considered.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi

adjuvant, desmuramyl peptides, immunostimulation, pathogen recognition receptors

Hrčak ID:

226603

URI

https://hrcak.srce.hr/226603

Posjeta: 861 *