Sažetak sa skupa

https://doi.org/10.15836/ccar2019.235

Association of gene polymorphism methylenetetrahydrofolate reductase cytosine-to-thymidine substitution at nucleotide 677 with cardiovascular and metabolic risk in morbidly obese patients

Rea Levicki orcid.org/0000-0003-3687-1310 ; Požega General County Hospital, Požega, Croatia
Juraj Jug ; University of Zagreb School of Medicine, Zagreb, Croatia
Ines Vinković ; University of Zagreb School of Medicine, Zagreb, Croatia
Filip Mustač ; University of Zagreb School of Medicine, Zagreb, Croatia
Martina Matovinović ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Lada Bradić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Jadranka Sertić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Martina Lovrić Benčić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia

Sažetak

Introduction: Region near the gene encoding methylenetetrahydrofolate reductase (MTHFR) is among eight
loci associated with blood pressure.1-3 The aim of this study is to show connection between polymorphism of
MTHFR C667T and hypertension, diabetes, prediabetes and obstructive sleep apnea in obese Croatian patients.
Patients and Methods: We included 88 patients
from a multidisciplinary weight management program
in which genetic analysis on MTHFR gene
polymorphism was tested. Patients were divided
in 3 groups: 36 patients with MTHFR C677T healthy
genotype CC (27 women, 9 men; age 46.4±10.1 year;
BMI 44.9±8.8 kg/m2), 38 patients with MTHFR
C677T heterozygous mutation CT (27 women, 11
men; age 46.9±11.4 year; BMI 44.6±8.6 kg/m2), 14
patients with MTHFR C677T homozygous mutation
TT (12 women, 2 men; age 50.1±15.5 year; BMI
40.2±6.9 kg/m2). In each group the incidence of hypertension,
prediabetes, diabetes and obstructive
sleep apnea (OSA) was determined.
Results: Patients with genetic mutation MTHFR
C677T:CT (Figure 1) had the highest incidence of
arterial hypertension (65.8%), diabetes (18.4%), prediabetes
(18.4%) and OSA (31.6%) with the highest
average apnea hypopnea index (AHI) of 17.3±24.7,
even 13.2% of patients used continuous positive
airway pressure (CPAP). Patients with healthy
genotype MTHFR C677T:CC had lower incidence
of arterial hypertension (44.4%), prediabetes (11.1%),
diabetes (13.9%), OSA (25%), average AHI 11.3±15.9
and only 8% of patients used CPAP. Patients with
MTHFR C677T:TT polymorphism had the lowest
arterial hypertension incidence (42.9%), the highest
prediabetes incidence (42.9%), middle OSA
prevalence (28.6%), AHI 7.7±7.6.
Conclusion: MTHFR C677T:CT polymorphism
is the most common gene polymorphism in
our group of morbidly obese patients. MTHFR
C677T:CT polymorphism compared to MTHFR
C677T:CC and MTHFR C677T:TT polymorphisms carries the highest risk for arterial hypertension, metabolic
disorders (diabetes) and obstructive sleep apnea. Homozygotes MTHFR C677T:TT carries the highest risk for
prediabetes. Further investigation is needed to explore this correlation.

Ključne riječi

methylenetetrahydrofolate reductase; hypertension; diabetes.

Hrčak ID:

226704

URI

https://hrcak.srce.hr/226704

Datum izdavanja:

15.10.2019.

Posjeta: 746 *