Liječnički vjesnik, Vol. 141 No. 9-10, 2019.
Pregledni rad
https://doi.org/10.26800/LV-141-9-10-39
Myelodysplastic syndrome in a patient with untreated chronic lymphoproliferative neoplasm
Ana Planinc-Peraica
; Klinička bolnica Merkur, Zagreb
Ana Reschner
; Dom zdravlja Zagreb – Centar, Zagreb
Morana Kosanović-Bajić
; Specijalna bolnica za plućne bolesti; Zagreb
Inga Mandac Rogulj
; Klinička bolnica Merkur, Zagreb
Gordana Kaić
; Klinička bolnica Merkur, Zagreb
Marin Kursar
; Klinička bolnica Merkur, Zagreb
Marko Martinović
; Klinička bolnica Merkur, Zagreb
Slobodanka Ostojić Kolonić
; Klinička bolnica Merkur, Zagreb
Delfa Radić-Krišto
; Klinička bolnica Merkur, Zagreb
Sažetak
High frequency of second malignancies is observed in chronic lymphoproliferative disease (LPD) patients. The simultaneous occurrence of myelodysplastic syndrome (MDS) with untreated LPD is extremely rare. Second haematological neoplasms are usually diagnosed incidentally during a routine clinical check-up, or due to
discordant clinical or laboratory findings. We are reporting diagnostic procedures, clinical course, and treatment of a 65-year-old woman with chronic lymphoproliferative neoplasm and MDS with excess of blasts type 2 (MDSEB2). Neutropenia was the most aberrant finding. A diagnosis of two malignant haematological neoplasms was done by cytological analysis and immunophenotyping of bone marrow and peripheral blood cells. In spite of treating both neoplasms no satisfactory results were achieved and MDS progressed to acute myeloid leukaemia. In patients with lymphoproliferative neoplasms and cytopenias it is important to find out other causes of these laboratory findings. In such patients the dominant disease should be treated. A concomitant MDS should be suspected and examined.
Ključne riječi
MYELODYSPLASTIC SYNDROMES – diagnosis, drug therapy; LYMPHOPROLIFERATIVE DISORDERS – diagnosis,drug therapy; ANTINEOPLASTIC AGENTS – therapeutic use; NEOPLASMS, MULTIPLE PRIMARY – diagnosis, drug therapy; NEUTROPENIA; DISEASE PROGRESSION; LEUKEMIA, MYELOID, ACUTE
Hrčak ID:
229524
URI
Datum izdavanja:
12.12.2019.
Posjeta: 2.132 *