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TUMORS IN KIDNEY DONORS – ETHIC DILEMMA IN TRANSPLANTATION MEDICINE

MARKO BANIĆ ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
ALAN HORVAT ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
LEA KATALINIĆ ; Klinički bolnički centar Zagreb, Klinika za urologiju, Zagreb, Hrvatska
VESNA FURIĆ-ČUNKO ; Klinički bolnički centar Zagreb, Klinika za urologiju, Zagreb, Hrvatska
IVANA JURIĆ ; Klinički bolnički centar Zagreb, Klinika za urologiju, Zagreb, Hrvatska
TVRTKO HUDOLIN ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
ŽELJKO KAŠTELAN ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
NIKOLINA BAŠIĆ-JUKIĆ orcid.org/0000-0002-0221-2758 ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju i Klinika za urologiju, Zagreb, Hrvatska

Sažetak

It is known that the incidence of malignant diseases is increased 3 to 4 times when the population of solid organs recipients is observed. Apart from the tumours developed from one's own tissues, tumour recipients may develop a malignant tumour related to the donated organ. The chance of developing such a disease is far smaller than the one of developing a malignant disease originating from one's own tissues but the chance is not non-existant. It is necessary to examine whether such a risk is worth taking and whether the donated organ should be explanted in the case of discovering a malignancy in donor. Another problem is the fact that a portion of such tumours is discovered not before the deceased donor's obduction. Acorrding to researches outside of Croatia, 0,01-0,05% of kidney recipients develop a malignancy transmitted from the donor. In Croatian terms, that would be equivalent to 0,02-0,1 persons per year. Increased risk groups would be donors over the age of 45 and donors with a history of malignant disease. There are no clear guidelines developed yet but there are some widely-accepted procedures in certain situations. Each patient must be individually evaluated and cost-benefit analysis must be taken into account. Four cases occured in the Hospital University Center Zagreb when the autopsy discovered a malignancy in kidney donors.

Ključne riječi

HIV; kidney transplantation; outcome; kidney transplantation; kidney donor; tumour; kidney recipient; ethics

Hrčak ID:

230108

URI

https://hrcak.srce.hr/230108

Datum izdavanja:

5.12.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 796 *