Ostalo

https://doi.org/10.20471/acc.2019.58.03.23

Gingival Ulcerations in a Patient with Acute Myeloid Leukemia: A Case Report and Literature Review

Vanja Vučićević Boras ; Department of Oral Medicine, School of Dental Medicine, University of Zagreb; Department of Oral Diseases, Zagreb University Hospital Centre, Zagreb, Croatia
Danica Vidović Juras ; Department of Oral Medicine, School of Dental Medicine, University of Zagreb; Department of Oral Diseases, Zagreb University Hospital Centre, Zagreb, Croatia
Igor Aurer ; Department of Hematology, School of Medicine and Zagreb University Hospital Centre, Zagreb, Croatia
Sandra Bašić-Kinda ; Department of Hematology, School of Medicine and Zagreb University Hospital Centre, Zagreb, Croatia
Mirta Mikulić ; Croatian Bone Marrow Donor Registry, Zagreb University Hospital Centre, Zagreb, Croatia

Sažetak

A 40-year-old female patient was admitted to the Department of Oral Medicine due to oral ulcerations. Oral ulcerations were present on vestibular mucosa above teeth 21, 22, 25 and 26 and were 1 cm in diam-eter, and also around teeth 45 and 46. The patient had prolonged neutropenia due to therapy-related myelodysplastic syndrome that progressed to therapy-related acute myeloid leukemia. Initially, the pa-tient was successfully treated with polychemotherapy for non-Hodgkin lymphoma. Unfortunately, many toxic complications ensued, such as peripheral neuropathy, dilated cardiomyopathy and therapy-related myelodysplastic syndrome/therapy-related acute myeloid leukemia. The onset of therapy-related myelo-dysplastic syndrome was less than six months after initiation of chemotherapy treatment, which was ra-ther early, but cytogenetic changes (monosomy 5 and 7) were consistent with the diagnosis. Upon admis-sion to our Department, microbiological swabs were obtained and were all negative, while x-ray finding showed that ulcerations did not have dental cause. Biopsy was not obtained as the patient had severe neutropenia and thrombocytopenia. While viral and fungal swabs were negative, Stenotrophomonas maltophilia was cultured from the oral cavity. Thus, differential diagnoses are listed in this report. Neutro-penic ulcerations did not heal albeit extensive medicamentous oral and systemic treatments were applied and the patient died.

Ključne riječi

Leukemia, myeloid, acute; Gingivitis, necrotizing, ulcerative; Case reports

Hrčak ID:

230287

URI

https://hrcak.srce.hr/230287

Datum izdavanja:

1.9.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.617 *